3-(2,4-Dimethoxyphenyl)heptanoic acid → 3-(2,4-Dimethoxyphenyl)hexanoic acid

HRID 1418205Notes

Reaction equation

HRID 1418205 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH:11]([CH2:16][CH2:17][CH2:18]C)[CH2:12][C:13]([OH:15])=[O:14].C([Mg]Br)CC>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH:11]([CH2:16][CH2:17][CH3:18])[CH2:12][C:13]([OH:15])=[O:14]

Participants

3

Reactant 2

HCID 193485383-(2,4-Dimethoxyphenyl)heptanoic acidHCID 178455851HCID 178455851, compound

Product 1

HCID 193488493-(2,4-Dimethoxyphenyl)hexanoic acid

Procedure

Following a similar procedure to that described in Preparation 42a, but using propylmagnesium bromide instead of butylmagnesium bromide, the title compound was obtained as an oily substance.

Sources & evidence

ORD record
ord-235d770c536841508e071275534393de
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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