3-Methoxypropyl 4-methylbenzenesulfonate → HCID 19348855, compound

HRID 1418217Notes

Reaction equation

HRID 1418217 reaction equation
[Cl:1][C:2]1[C:3]([OH:20])=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12]C)=[O:11])[CH:7]=1.[CH3:21][O:22][CH2:23][CH2:24][CH2:25]OS(C1C=CC(C)=CC=1)(=O)=O>CCOCC>[Cl:1][C:2]1[C:3]([O:20][CH2:25][CH2:24][CH2:23][O:22][CH3:21])=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([OH:12])=[O:11])[CH:7]=1

Participants

4

Reactant 2

HCID 135229883-Methoxypropyl 4-methylbenzenesulfonateHCID 19348793HCID 19348793, compound

Product 1

HCID 19348855HCID 19348855, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(5-chloro-4-hydroxy-2-methoxyphenyl)heptanoate (prepared as described in Preparation 56B) and 3-methoxy-1-tosyloxypropane, the corresponding ether derivative was obtained. Hydrolysis of this derivative and subsequent treatment of the reaction mixture were conducted in a similar manner to that described in Preparation 7 to give the title compound as a viscous substance.

Workup

  1. customthat described in Preparation 45A(i)
  2. customHydrolysis of this derivative and subsequent treatment of the reaction mixture
  3. customdescribed in Preparation 7

Sources & evidence

ORD record
ord-3993263bdb1242fc8ea6abeefea62725
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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