Sodium Hydroxide → 3,5-Dinitrostyrene

Participants

Reaction Conditions

Reaction Steps

3,5-Dinitrophenylethanol (1.0 g, 4.7 mmol) was mixed with P2O5 (1.0 g, 0.71 mmol) and the stirred mixture was heated to 100° C. After 3 h, the mixture was allowed to cool to room temperature and water (0.4 ml) was added. The pH was adjusted to 9 using 1M aqueous NaOH and extracted with diethyl ether (2×25 ml). The combined organic phases were dried (Na2SO4) and evaporated. The crude product was used without further purification in the next step.

Provenance & Evidence