Bromocyclopentane → HCID 131721161, compound

Participants

Reaction Steps

An acetonitrile (20 mL) solution of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-5,6-dihydroimidazo [1,5-a] pyridine-1,3[2H, 7H]-dione (0.46 g, 1.54 mmol), potassium carbonate (0.16 g, 1.16 mmol) and cyclopentylbromide (0.18 mL, 1.69 mmol) was stirred for 2 hours under reflux. A saturated ammonium chloride solution (20 mL) and diethyl ether (20 mL) were added to the resulting mixture, and the organic layer was separated and then the aqueous layer was extracted with diethyl ether (20 mL×2 times). The organic layer combined was washed with a saturated sodium chloride solution (25 mL) and dried over anhydrous magnesium sulfate. After removal of magnesium sulfate by filtration, the filtrate was evaporated to give crude product, which was purified by silica gel column (Wakogel C-200, ethyl acetate/hexane=1/1) to obtain a pale yellow oil of 2-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)-5,6-dihydroimidazo [1,5-a] pyridine-1,3[2H, 7H]-dione (0.49 g, yield:87.5%).

Provenance & Evidence