Hydrochloric Acid → HCID 131721175, compound

Participants

Reaction Steps

A methanol (10 mL) solution of 2-(2,4-dichloro-5-methoxycarbonyloxyphenyl)-5,6-dihydroimidazo [1,5-a] pyridine-1,3[2H, 7H]-dione (0.50 g, 1.35 mmol) and potassium carbonate (0.19 g, 1.35 mmol) was stirred at 50°-60° C. for 2 hours. 1N Hydrochloric acid (20 mL) was added to the resulting mixture, and the organic layer was separated and then the aqueous layer was extracted with ethyl acetate (10 mL×2 times). The organic layer combined was washed with a saturated sodium chloride solution (30 mL) and dried over anhydrous magnesium sulfate. After removal of magnesium sulfate by filtration, the filtrate was evaporated to give a white solid of 2-(2,4-dichloro-5-hydroxyphenyl)-5,6-dihydroimidazo [1,5-a] pyridine-1,3[2H, 7H]-dione (0.34 g, yield:81.0%).

Provenance & Evidence