HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 15859133, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 1810419 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 15859133 | HCID 15859133 | 103.3% |
Reaction Steps
A mixture of 5.0 gm of 1-t-butoxycarbonyl piperazine, 6.26 gm of 1-(3-chloro propyl)-2,3-dihydro-1H-benzimidazol-2-one (available from Janssen) and 4.16 gm diisopropylethylamine in 150 ml ethanol is kept for 12 hours at 80° C. Upon cooling to ambient temperature, 100 ml water is added and the mixture is extracted with chloroform (CHCl3) and the extract is collected, washed with 20 ml water and dried over Na2SO4. After removing the solvents, 10 gm of a yellowish oil is obtained which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05883094 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-d7b45532adda4e88b1fd4239a73661b2 |
| Source note | uspto-grants-1999_03 |