1,3-Propanediol → 4-t-butyl-N-[6-(3-hydroxypropyloxy)-2-(4-isopropylpiperazinyl)-5-(2-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	1,3-Propanediol	HCID 10442	—
Reactant	4-t-butyl-N-[6-chloro-2-(4-isopropylpiperazinyl)-5-(2-methoxyphenoxy)-4-pyrimidinyl]-benzenesulfonamide	HCID 86753874	—
Product	4-t-butyl-N-[6-(3-hydroxypropyloxy)-2-(4-isopropylpiperazinyl)-5-(2-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide	HCID 70022255	—

Reaction Steps

The procedure described in Synthesis Example 3 was repeated by use of 4-t-butyl-N-[6-chloro-2-(4-isopropyl -piperazinyl)-5-(2-methoxyphenoxy)-4-pyrimidinyl]-benzenesulfonamide and 1,3-propanediol, to thereby obtain the title compound as a pale yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05883092
Source dataset	uspto-grants-1999_03
ORD ID	ord-94020c71235a41b48f3eb01b5cd17309
Source note	uspto-grants-1999_03