1,3-Propanediol → HCID 70021308, compound

HRID 1418342Notes

Reaction equation

HRID 1418342 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[C:20]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[C:19](Cl)[N:18]=[C:17]([N:31]3[CH2:37][CH2:36][CH2:35][N:34]([CH3:38])[CH2:33][CH2:32]3)[N:16]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:39]([OH:43])[CH2:40][CH2:41][OH:42]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[C:20]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[C:19]([O:42][CH2:41][CH2:40][CH2:39][OH:43])[N:18]=[C:17]([N:31]3[CH2:37][CH2:36][CH2:35][N:34]([CH3:38])[CH2:33][CH2:32]3)[N:16]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 104421,3-PropanediolHCID 86753876HCID 86753876, compound

Product 1

HCID 70021308HCID 70021308, compound

Procedure

The procedure described in Synthesis Example 3 was repeated by use of 4-t-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(4-methylhomopiperazinyl)-4-pyrimidinyl]benzenesulfonamide and 1,3-propanediol, to thereby obtain the title compound as a pale yellow oil.

Workup

  1. customThe procedure described in Synthesis Example 3

Sources & evidence

ORD record
ord-ace416d6002041dfa189e93a175636ac
Source dataset
uspto-grants-1999_03
Patent number
US05883092

Reaction notes

Loading…