HRID1418344

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID82191

1-Piperazinecarboxaldehyde

C5H10N2O

结构：COc1ccccc1Oc1c(Cl)nc(Cl)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1

HCID86753872

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1Oc1c(Cl)nc(N2CCN(C=O)CC2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1

HCID86753877

未命名化合物

PROCEDURE

实验过程

The procedure described in Synthesis Example 2 was repeated by use of 4-t-butyl-N-[2,6-dichloro-5-(2 -methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide (5) and 1-formylpiperazine, to thereby obtain the title compound as a pale yellow oil.

WORKUP

后处理

customThe procedure described in Synthesis Example 2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f2b8757dc0147d8b90feb78703e1bbc
来源数据集: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05883092
来源说明: uspto-grants-1999_03

反应 SMILES

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[C:20]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[C:19]([Cl:30])[N:18]=[C:17](Cl)[N:16]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH:32]([N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)=[O:33]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[C:20]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[C:19]([Cl:30])[N:18]=[C:17]([N:37]3[CH2:38][CH2:39][N:34]([CH:32]=[O:33])[CH2:35][CH2:36]3)[N:16]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]