2-Isopropylaniline → HCID 54379034, compound

HRID 1418348Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[C:18]([O:20][CH2:21][CH2:22][C:23](O)=[O:24])[C:17]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[O:33][CH3:34])=[C:16]([NH:35][S:36]([C:39]3[CH:44]=[CH:43][C:42]([C:45]([CH3:48])([CH3:47])[CH3:46])=[CH:41][CH:40]=3)(=[O:38])=[O:37])[N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:49]([C:52]1[CH:58]=[CH:57][CH:56]=[CH:55][C:53]=1[NH2:54])([CH3:51])[CH3:50]>>[CH:49]([C:52]1[CH:58]=[CH:57][CH:56]=[CH:55][C:53]=1[NH:54][C:23](=[O:24])[CH2:22][CH2:21][O:20][C:18]1[C:17]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][CH3:34])=[C:16]([NH:35][S:36]([C:39]2[CH:40]=[CH:41][C:42]([C:45]([CH3:48])([CH3:46])[CH3:47])=[CH:43][CH:44]=2)(=[O:37])=[O:38])[N:15]=[C:14]([N:11]2[CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:13][CH2:12]2)[N:19]=1)([CH3:51])[CH3:50]

Participants

Reactant 2

HCID 125612-Isopropylaniline

HCID 53747506HCID 53747506, compound

Product 1

HCID 54379034HCID 54379034, compound

Procedure

The procedure described in Example 2 was repeated by use of 3-[2-(4-t-butoxycarbonylpiperazinyl)-6-(4-t-butyl-phenylsulfonylamino)-5-(2-methoxyphenoxy)-4-pyrimidinyloxy]-propionic acid and 2-isopropylaniline, to thereby obtain the title compound as a pale yellow oil.

Sources & evidence

ORD record: ord-79d268f04cc043278896191fcafd6858
Source dataset: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05883092

Reaction notes

Loading…