Ethyl 3-oxopyrrolidine-1-carboxylate → HCID 67569307, compound

HRID 1418390Notes

Reaction equation

HRID 1418390 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([NH2:7])=[NH:6].O=[C:13]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:14]1>>[ClH:1].[NH2:6][C:5]1[C:4]2[C:3](=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:2][C:13]2([CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:14]2)[N:7]=1

Participants

3

Reactant 2

HCID 277754Ethyl 3-oxopyrrolidine-1-carboxylateHCID 18468824HCID 18468824, compound

Product 1

HCID 67569307HCID 67569307, compound

Procedure

This was prepared by the method of Example 173 using 2-aminobenzamidine hydrochloride and ethyl 3-oxopyrrolidine-1-carboxylate to give the title compound, MS (+EI) 274 ([M+H]+), 1H NMR (d6 -DMSO) (rotamers) 10.48 (1H, s), 9.2-8.2 (2H, m), 7.94 (1H, s), 7.88 (1H, d), 7.49 (1H, t), 6.89 (1H, d), 6.85 (1H, t), 4.04 (2H, dt), 3.6-3.4 (4H, m) 2.86-2.7 (1H, m), 2.09-2.02 (1H, m), 1.18 (3H, dq).

Sources & evidence

ORD record
ord-75506e02941c4540aedbd293f323fc6c
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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