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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1418472Generated: October 27, 2026

4-(2-Methylimidazol-1-yl)benzyl chloride hydrochloride → 4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide

https://huagongshe.com/reaction/1418472

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(2-Methylimidazol-1-yl)benzyl chloride hydrochlorideHCID 18786342—
Reactant4-(3-Hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxamideHCID 18786355—
Product4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamideHCID 11176798—

Reaction Steps

4-(3-Hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide was reacted with 4-(2-methylimidazol-1-yl)benzyl chloride hydrochloride according to the procedure described in Example 2H to give the titled compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05883106
Source datasetuspto-grants-1999_03
ORD IDord-daf4cd61f5c74b14b27221ef51554808
Source noteuspto-grants-1999_03