CJ-13454 → 4-[5-Fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide hydrochloride

HRID 1418474Notes

Reaction equation

HRID 1418474 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH:29]=[CH:28][N:27]=[C:26]3[CH3:30])=[CH:21][CH:20]=2)[CH:5]=[C:6]([C:8]2([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1.[ClH:31].CO>>[ClH:31].[F:1][C:2]1[CH:3]=[C:4]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH:29]=[CH:28][N:27]=[C:26]3[CH3:30])=[CH:21][CH:20]=2)[CH:5]=[C:6]([C:8]2([C:14]([NH2:16])=[O:15])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 9931329CJ-13454HCID 21893726Hydrochloride methanol

Product 1

HCID 187863164-[5-Fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide hydrochlorideYield 57%

Procedure

4-[5-Fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-tetrahydro-2H-pyran-4-carboxamide (39 mg, 0.1 mmol) was dissolved in 10% hydrogen chloride-methanol (2 ml). After stirring for 10 min, volatiles were removed by evaporation and the resulting residue recrystallized from ethanol to give the titled compound (24 mg, 57%) as white solids.

Workup

  1. customvolatiles were removed by evaporation
  2. customthe resulting residue recrystallized from ethanol

Sources & evidence

ORD record
ord-0b0996dfcc504d0b8e37a54a7ae85ac2
Source dataset
uspto-grants-1999_03
Patent number
US05883106

Reaction notes

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