Fumaric Acid → HCID 131721186, compound

HRID 1418475Notes

Reaction equation

HRID 1418475 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([S:13][C:14]3[CH:15]=[C:16]([C:20]4([C:26]([NH2:28])=[O:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)[CH:17]=[CH:18][CH:19]=3)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>CO>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[CH:9][C:10]([S:13][C:14]3[CH:15]=[C:16]([C:20]4([C:26]([NH2:28])=[O:27])[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)[CH:17]=[CH:18][CH:19]=3)=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1.[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[CH:9][C:10]([S:13][C:14]3[CH:15]=[C:16]([C:20]4([C:26]([NH2:28])=[O:27])[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)[CH:17]=[CH:18][CH:19]=3)=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 98219454-(3-{[4-(2-methyl-1H-imidazol-1-yl)phenyl]sulfanyl}phenyl)tetrahydro-2H-pyran-4-carboxamide

Product 1

HCID 131721186HCID 131721186, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

b 4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide (39 mg, 0.1 mmol) and fumaric acid (12 mg, 0.1 mmol) were dissolved in methanol (3 ml). After stirring for 10 min, volatiles were removed by evaporation and the resulting residue recrystallized from 2-propanol to give the titled compound (40 mg, 78%) as white solids.

Workup

  1. customvolatiles were removed by evaporation
  2. customthe resulting residue recrystallized from 2-propanol

Sources & evidence

ORD record
ord-1fa1f2709c9e4ae180a47c7069dd2ee7
Source dataset
uspto-grants-1999_03
Patent number
US05883106

Reaction notes

Loading…