1,2-Dibromoethane → 1-[3-[4-(2-Methylimidazol-1-yl)benzyloxy]phenyl]cyclopropane-1-carboxamide

HRID 1418480Notes

Reaction equation

HRID 1418480 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:27]=[CH:26][C:10]([CH2:11][O:12][C:13]3[CH:14]=[C:15]([C:19]4([C:23]([NH2:25])=[O:24])[CH2:22]C[CH2:20]4)[CH:16]=[CH:17][CH:18]=3)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.BrCCBr>>[CH3:1][C:2]1[N:3]([C:7]2[CH:27]=[CH:26][C:10]([CH2:11][O:12][C:13]3[CH:14]=[C:15]([C:19]4([C:23]([NH2:25])=[O:24])[CH2:22][CH2:20]4)[CH:16]=[CH:17][CH:18]=3)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1

Participants

3

Reactant 2

HCID 78391,2-DibromoethaneHCID 153921311-[3-[4-(2-Methylimidazol-1-yl)benzyloxy]phenyl]cyclobutane-1-carboxamide

Product 1

HCID 153921321-[3-[4-(2-Methylimidazol-1-yl)benzyloxy]phenyl]cyclopropane-1-carboxamide

Procedure

The titled compound was prepared according to the procedure described for 1-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclobutane-1-carboxamide except that 1,2-dibromoethane was used in place of 1,3-dibromopropane (Example 20).

Sources & evidence

ORD record
ord-fcab8396109c4a61ba73b031304267da
Source dataset
uspto-grants-1999_03
Patent number
US05883106

Reaction notes

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