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4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran → 4-Cyano-4-[3-[4-(1,2,4-triazol-4-yl)phenyl]thiophenyl]-3,4,5,6-tetrahydro-2H-pyran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran | HCID 11360872 | — |
| 反応物 | (2SR,4RS)-4-cyano-2-methyl-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran | HCID 18786333 | — |
| 反応物 | (2SR,4RS)-4-cyano-2-methyl-4-[3-[4-(2-methylimidazol-1-yl) phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran | HCID 18786347 | — |
| 反応物 | HCID 178506541 | HCID 178506541 | — |
| 生成物 | 4-Cyano-4-[3-[4-(1,2,4-triazol-4-yl)phenyl]thiophenyl]-3,4,5,6-tetrahydro-2H-pyran | HCID 54099620 | — |
反応手順
The titled compound was prepared according to the procedure described in example 29E for the preparation of (2SR,4RS)-4-cyano-2-methyl-4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran using 4-(triazol-4-yl)phenyl iodide and 4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran in place of 4-(2-methylimidazol-1-yl)phenyl iodide and (2SR,4RS)-4-cyano-2-methyl-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran, respectively. MS(EI):m/z 362(M+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05883106 |
| 出典データセット | uspto-grants-1999_03 |
| ORD ID | ord-1e616f0cc95d40f1b89c7697a15b7092 |
| 出典メモ | uspto-grants-1999_03 |