HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1418525Generated: October 30, 2026
Oxindole → 3-[(2-Methylmercaptothien-5-yl)methylene]-2-indolinone
https://huagongshe.com/reaction/1418525
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | 5-(Methylsulfanyl)thiophene-2-carbaldehyde | HCID 2736997 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(2-Methylmercaptothien-5-yl)methylene]-2-indolinone | HCID 69631126 | 90% |
Reaction Steps
A reaction mixture of 134.0 mg of oxindole, 189.9 mg of the 5-methylmercaptothiophene-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 246.6 mg (90%) of the title compound as a orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05883116 |
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| Source dataset | uspto-grants-1999_03 |
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| ORD ID | ord-a16a07ec908a40fcb7e650d9bde27c36 |
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| Source note | uspto-grants-1999_03 |
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