Lactic Acid → HCID 10130434, compound

Participants

Reaction Conditions

Reaction Steps

The lactide obtained in Example 2 (17 g) and ε-caprolactone (3 g) were put into a 100-ml reaction vessel equipped with a stirrer and a nitrogen-introducing tube. After substitution of nitrogen gas was carried out three times, the mixture was molten by stirring at 150° C. for 3 hours in a stream of nitrogen. To the resulting mixture was added 0.4 g of synthetic light aluminum silicate (Tomita Pharmaceutical Co., Ltd.), and the temperature was raised to 195°±5° C. The pressure was reduced gradually to 20 mmHg over 30 minutes, followed by stirring at 195°±5° C. for 3 hours. After the pressure was reduced gradually to 1 mmHg over 30 minutes, the mixture was stirred at 195°±5° C. for 7 hours to give lactic acid-caprolactone copolymer in the molten state. The product was cooled to room temperature to give 12.11 g of light brown copolymer. The weight-average molecular weight of this copolymer was 82,000.

Provenance & Evidence