HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 54005465, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | Methyl 2-bromo-5-methoxybenzoate | HCID 2776849 | — |
| Reactant | HCID 178498550 | HCID 178498550 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 54005465 | HCID 54005465 | — |
Reaction Steps
methyl 2-[3-(hexahydro-7-imino-1H-azepin-2-yl)-1-propenyl]-5-methoxybenzoate, monohydrochloride ##STR201## 200 A) The Isomer B title material of Example 18 in acetonitrile is coupled to methyl 2-bromo-5-methoxybenzoate in the presence of palladium acetate, tri-o-tolylphosphine, and triethylamine by the method of Example 32 to provide methyl 2-[3-(hexahydro-7-oxo-1H-azepin-2-yl)-1-propenyl]-5-methoxybenzoate as primarily its E isomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05883251 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-5873079439604aacbe6668634be27dca |
| Source note | uspto-grants-1999_03 |