Trifluoroacetic acid → HCID 53746879, compound

Participants

Reaction Steps

To a stirring suspension of (±)-8-methyl-7-[1-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]oxy]propyl]indolizino[1,2-b]quinolin-9(11H)-one (1.15 g, 2.5 mmol) in 1,3-dimethoxybenzene (12 mL) under an argon atmosphere was added trifluoroacetic acid (13 mL). After stirring for 1.5 h at room temperature, the mixture was concentrated under reduced pressure. The residue was dissolved in H2O, extracted with Et2O, filtered and lyophilized to afford the title compound as a pale yellow solid. 1H NMR (DMSO-d6) d 8.68 (s, 1H), 8.24 (m, 1H), 8.13 (m, 1H), 7.86 (apparent br t, 1H), 7.70 (apparent br t, 1H), 7.19 (s, 1H), 5.91 (apparent br t, 1H), 5.26 (s, 2H), 4.02 (br s, 2H), 2.25 (s, 3H), 2.06-1.81 (m, 2H), 0.96 (t, J=7.2Hz, 3H). Anal. Calcd for C21H21N3O3.CF3CO2H.9/4 H2O; C, 53.33; H, 5.16; N, 8.11. Found: C, 53.09; H, 4.91; N, 7.74.

Provenance & Evidence