Trifluoroacetic acid water → HCID 54288547, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 3B except using (±)-2-cyano-8-methyl-7-[1-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]oxy]propyl]indolizino[1,2-b]quinolin-9(11H)-one. 1H NMR (DMSO-d6) d 8.81 (d, J=1.5 Hz, 1H), 8.77 (s, 1H), 8.27 (d, J=8.9 Hz, 1H), 8.13 (dd, J=8.9, 1.8 Hz, 1H), 7.24 (s, 1H), 5.91 (apparent br t, J=6.7 Hz, 1H), 5.29 (s, 2H), 3.98 (br s, 2H), 2.26 (s, 3H), 2.05-1.81 (m, 2H), 0.96 (t, J=7.4 Hz, 3H). Anal. Calcd for C22H20N4O3.3/2 CF3CO2H.H2O: C, 52.00; H, 4.10; N, 9.70. Found: C, 52.04; H, 4.32; N, 9.73.

Provenance & Evidence