Trifluoroacetic acid water → HCID 54029977, compound

HRID 1418704Notes

Reaction equation

[CH3:1][C:2]1[C:3](=[O:36])[N:4]2[C:29](=[CH:30][C:31]=1[C:32](=[O:35])[CH2:33][CH3:34])[C:7]1=[N:8][C:9]3[C:14]([C:15]([CH2:16][O:17][C:18](=[O:28])[CH2:19][NH:20]C(OC(C)(C)C)=O)=[C:6]1[CH2:5]2)=[CH:13][CH:12]=[CH:11][CH:10]=3.C(C(O)=O)(F)(F)F.O>>[NH2:20][CH2:19][C:18]([O:17][CH2:16][C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]2[C:29]3[N:4]([CH2:5][C:6]=12)[C:3](=[O:36])[C:2]([CH3:1])=[C:31]([C:32](=[O:35])[CH2:33][CH3:34])[CH:30]=3)=[O:28]

Participants

Reactant 2

HCID 22392675Trifluoroacetic acid water

HCID 86753929HCID 86753929, compound

Product 1

HCID 54029977HCID 54029977, compound

Procedure

The title compound was prepared according to the procedure in Example 5B except using 8-methyl-12-[[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]oxy]methyl]-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-one. 1H NMR (D2O/DSS) d 7.6-7.3 (m, 4H), 6.64 (s, 1H), 5.58 (s, 2H), 4.58 (s, 2H), 4.20 (s, 2H), 2.92 (q, J=7.2 Hz, 2H), 1.94 (s, 3H), 1.22 (t, J=7.2 Hz, 3H). Anal. Calcd for C22H21N3O4.CF3CO2H.H2O: C, 55.07; H, 4.62; N, 8.03. Found: C, 55.32; H, 4.69; N, 7.98.

Sources & evidence

ORD record: ord-8ed09562a15d4e25ae93bed9f213502c
Source dataset: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05883255

Reaction notes

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