Ammonia → HCID 13934548, compound

Participants

Reaction Steps

β-L-ribopyranosylcytosine triacetate (7) was deprotected by treating with 2.0M methanolic ammonia (80 ml for 10 mmol nucleoside) for 24 h at room temperature. The methanolic ammonia was evaporated in vacuo and the residue was purified by flash chromatography on silica gel (150 g) with chloroform-methanol-water (65:35:4) eluent to give (8) 0.8 g (17% overall yield) of white needles. TLC:Rf =0.17 in chloroform-methanol-water (65:35:4) as a mobile phase.

Provenance & Evidence