Ammonia → (2-Fluorophenyl)thiourea

HRID 1418857Notes

Reaction equation

HRID 1418857 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[S:10].[NH3:11]>CCOCC>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([NH2:11])=[S:10]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 975202-Fluorophenyl isothiocyanate

Product 1

HCID 2737500(2-Fluorophenyl)thiourea

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a stirred solution of 7.0 g (0.045 mol) of 2-fluorophenyl isothiocyanate in 100 ml of ether, was added ammonia gas over a three minute period. A white solid crystallized and was collected by filtration to yield 5.3 g of N-(2-fluorophenyl)thiourea, melting point 147°-148° C.

Workup

  1. customA white solid crystallized
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-abd905e5aef540f8b54364f7db89e66f
Source dataset
uspto-grants-1999_03
Patent number
US05885985

Reaction notes

Loading…