Methanol → 3-(2-Quinazolinylmethoxy)benzyl chloride

HRID 1418866Notes

Reaction equation

HRID 1418866 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16]O.CO.C(Cl)(Cl)[Cl:24]>O=S(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][Cl:24]

Participants

5

Reactant 3

HCID 887MethanolHCID 6212ChloroformHCID 543359633-(2-Quinazolinylmethoxy)benzyl alcohol

Product 1

HCID 540176783-(2-Quinazolinylmethoxy)benzyl chloride

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

To a solution of 1.00 g (3.76 mmol) of 3-(2-quinazolinylmethoxy)benzyl alcohol in 10 ml of CHCl3, 0.5 ml of SOCl2 was added, followed by stirring at room temperature for 15 hours. A small amount of MeOH was added to the reaction mixture and the solvents were distilled off under reduced pressure, whereby 1.08 g of 3-(2-quinazolinylmethoxy)benzyl chloride were obtained as white powder.

Workup

  1. distillationthe solvents were distilled off under reduced pressure

Sources & evidence

ORD record
ord-0e938843bbb845baad9492ecff9c5342
Source dataset
uspto-grants-1999_03
Patent number
US05885987

Reaction notes

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