1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 9907689, compound

HRID 1418890Notes

Reaction equation

HRID 1418890 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.C[C:18]1[CH:19]=[C:20]([N:25]2CC[NH:28][CH2:27][CH2:26]2)[CH:21]=[CH:22][C:23]=1[CH3:24]>>[F:16][C:2]([F:1])([F:15])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:24][C:23]3[CH:22]=[C:21]4[C:20](=[CH:19][CH:18]=3)[NH:25][CH2:26][CH2:27][NH:28]4)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 27237821-(3,4-Xylyl)piperazine

Product 1

HCID 9907689HCID 9907689, compound

Procedure

Example 11 was prepared according to Example 2 except that in Step A 1-(3-trifluoromethylphenyl)piperazine is substituted for 1-(3,4-dimethylphenyl)piperazine; mp 88°-91° C.

Workup

  1. customExample 11 was prepared

Sources & evidence

ORD record
ord-825f9ba32a0241989bf3260c132e8f22
Source dataset
uspto-grants-1999_03
Patent number
US05885994

Reaction notes

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