Hydrochloric Acid → HCID 86753942, compound

Participants

Reaction Steps

1.13 g (0.00257 mol) of (S)-8-chloro-1-(5-dipropylaminomethyl-oxazol-2-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]-imidazo[1,5-a][1,4]benzodiazepin-9-one in 50 ml ethanol were treated at 0° with 0.73 ml (0.00270 mol) of 3.7N ethanolic hydrochloric acid. A suspension was obtained after stirring at 0° for 1/4 hr. It was treated with 50 ml of ether and suction filtered. There was obtained 1.0 g (82%) of (S)-8-chloro-1-(5-dipropylaminomethyl-oxazol-2-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one hydrochloride (1:1) as white crystals; m.p. 237°-240° (dec.) and [α]D20 =-163.4° (H2O, c=1%).

Provenance & Evidence