Hydrochloric Acid → HCID 86753945, compound

Participants

Reaction Steps

1.15 g (0.00255 mol) of (S)-8-chloro-1-(5-diallylaminomethyl-oxazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one in 20 ml of ethanol were treated with 0.53 ml (0.00253 mol) of 4.78N ethanolic hydrochloric acid at 0°. After stirring at 0° for 10 minutes the colorless solution was completely freed from the solvents. The residue was dissolved in hot ethanol and recrystallized by the addition of ether. There was obtained 0.9 g (78%) of (S)-8-chloro-1-(5-diallylaminomethyl-oxazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride (1:1) as beige crystals; m.p. 169°-171° and [α]D20 =+7.70 (MeOH, c=1%).

Provenance & Evidence