Hydrochloric Acid → HCID 86753946, compound

Participants

Reaction Steps

1.13 g (0.00283 mol) of 3-(5-dipropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a]thieno[2,3-f][1,4]-diazepin-6-one in 50 ml of ethyl acetate were treated with 0.84 ml (0.00311 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the suspension was suction filtered. The yellowish crystals were dissolved in hot acetonitrile and recrystallized by the addition of ether. There were obtained 1.05 g (85%) of 3-(5-dipropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepin-6-one hydrochloride (1:1) as light beige crystals; m.p. 237°-241° (dec.).

Provenance & Evidence