HCID 15858426, compound → HCID 15858428, compound

Participants

Reaction Steps

9.2 g of 3-[(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpyridine was dissolved in 120 ml of acetic acid, and 1 g of platinum oxide was added. A hydrogenation reaction was carried out at 3 atmospheric pressure for 8.5 hours. After completion of the reaction, the catalyst was filtered off and the solvent was concentrated. After adding ice pieces to the residue and alkalizing it with 50% aqueous sodium hydroxide solution, it was extracted three times with dichloromethane. After drying the extract solution, it was distilled off and purified by a silica gel chromatography (dichloromethane/methanol 30:1-10:1-3:1) to obtain 3.7 g of oily 3-[(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine.

Provenance & Evidence