Methylhydrazine → HCID 15411027, compound

HRID 1419070Notes

Reaction equation

HRID 1419070 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[C:5](=O)[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:18][NH:19][NH2:20]>C(O)C>[OH:1][C:2]1[CH:3]=[C:4]([C:5]2[CH2:6][CH:7]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:19]([CH3:18])[N:20]=2)[CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 244688HCID 244688, compound

Product 1

HCID 15411027HCID 15411027, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 100 ml round bottom flask equipped with a magnetic stirrer and reflux condenser was charged 1.0 g (0.0045 moles) of 3'-hydroxychalcone, and 25 mls of absolute ethanol. To this solution was then added 0.21 g (0.0045 moles) of methyl hydrazine in one portion. The reaction was then heated to reflux for two hours, then cooled. The solvent was removed under reduced pressure to afford 1.1 g of 3-(3-hydroxylphenyl)-1-methyl-5-phenyl-2-pyrazoline as a thick brown oil in 97% yield

Workup

  1. customTo a 100 ml round bottom flask equipped with a magnetic stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction was then heated
  4. temperatureto reflux for two hours
  5. temperaturecooled
  6. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-6cc39df90a5b42e3b95e125e5d3059d9
Source dataset
uspto-grants-1999_03
Patent number
US05886015

Reaction notes

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