Acetic Anhydride → HCID 9956228, compound

Participants

Reaction Steps

0.032 ml of acetic anhydride were added at room temperature to a solution of 0.12 g of 5-[4-(5-hydroxy-1,4,6,7-tetramethylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione (prepared as described in Example 3) in 2 ml of pylidine, and the resulting mixture was stirred for 3 hours, after which it was allowed to stand overnight. At the end of this time, the reaction mixture was freed from the solvent by evaporation under reduced pressure, and the resulting residue was mixed with water. The aqueous mixture was then extracted with ethyl acetate. The extract was washed with water and then with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, after which the solid residue was triturated with diethyl ether and collected by filtration. It was then washed with diethyl ether, to give 0.12 g of the title compound, melting at 250°-253° C.

Provenance & Evidence