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Hydrochloric Acid → 4-Methoxy-N-methyl-2-nitrobenzenamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | tert-butyl N-(4-methoxy-2-nitrophenyl)-N-methylcarbamate | HCID 53900404 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-Methoxy-N-methyl-2-nitrobenzenamine | HCID 3554313 | 90.6% |
反応手順
A procedure similar to that described in Preparation 8 was repeated, except that 2.0 g of N-t-butoxycarbonyl-N-methyl-4-methoxy-2-nitroaniline (prepared as described in Preparation 23) and 30 ml of a 4N solution of hydrogen chloride in 1,4-dioxane were used, to give 1.17 g of the title compound having an Rf value=0.62 (on thin layer chromatography on silica gel; developing solvent: a 1:5 by volume mixture of ethyl acetate and hexane).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05886014 |
| 出典データセット | uspto-grants-1999_03 |
| ORD ID | ord-d6fe830b6cb54433860642699266d1f2 |
| 出典メモ | uspto-grants-1999_03 |