HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1419139Generated: October 26, 2026
ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate → ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
https://huagongshe.com/reaction/1419139
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate | HCID 137485 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate | HCID 5654 | 79% |
Reaction Steps
A reaction mixture of 134.0 mg of oxindole, 234.3 mg of the 4-ethoxycarbonyl-3,5-dimethylpyrrole-2-carboxaldehyde, and 3 drops of piperidine in 3 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 244.6 mg (79%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05886020 |
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| Source dataset | uspto-grants-1999_03 |
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| ORD ID | ord-737b66683a4c4962ac379f24bc4a1f6b |
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| Source note | uspto-grants-1999_03 |
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