反应详情

5-(4-Cyano-2-nitrophenyl)amino-3-(N-t-butoxycarbonyl-1,2,5,6-tetrahydropyrid-4-yl)-1H-indole was used. Reduction was by catalytic hydrogenation, the cyclization reaction used ethoxymethylene malononitrile, and the cyclization reaction was heated for 48 hours. Chromatography using 10% ethyl acetate in methylene chloride afforded the title compound (10%) as a brown foam: Rf =0.2 in 10% ethyl acetate in methylene chloride; HRMS calculated for C26H27N5O2 441.2167, found 441.2169.

1. customthe cyclization reaction
2. customthe cyclization reaction
3. temperaturewas heated for 48 hours