Methanol → HCID 54548004, compound

HRID 1419214Notes

Reaction equation

HRID 1419214 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Br:12])[CH:8]=2)[C:3]=1[CH2:13][C:14]([OH:16])=[O:15].S(=O)(=O)(O)O.[CH3:22]O>>[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Br:12])[CH:8]=2)[C:3]=1[CH2:13][C:14]([O:16][CH3:22])=[O:15]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 53984903HCID 53984903, compound

Product 1

HCID 54548004HCID 54548004, compound

Procedure

126.5 Grams of 2-hydroxy-6-bromo-1-naphthylacetic acid, 700 ml of methanol and 2 ml of concentrated sulfuric acid were stirred at room temperature for 24 hours. Then, the reaction mixture was concentrated under reduced pressure. The precipitate was collected by filtration and washed with small amounts of methanol and water to obtain 125.5 g of the desired product.

Workup

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with small amounts of methanol and water

Sources & evidence

ORD record
ord-49257b6d4fe746dbb53a934f50a5a20a
Source dataset
uspto-grants-1999_03
Patent number
US05885990

Reaction notes

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