HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-amidino-1-carbamoylmethyl-2-naphthyl 3-[(4,5-dihydro-1H-imidazol-2-yl)amino]-benzoate.dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoic acid.hydrochloride | HCID 70130382 | — |
| Reactant | 6-Amidino-1-carbamoylmethyl-2-naphthol.hydrochloride | HCID 136454270 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-amidino-1-carbamoylmethyl-2-naphthyl 3-[(4,5-dihydro-1H-imidazol-2-yl)amino]-benzoate.dihydrochloride | HCID 70130389 | 66.6% |
Reaction Steps
15 Milliliters of 20% hydrous pyridine was added to 634.1 mg of 3-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoic acid.hydrochloride, 676.7 mg of 6-amidino-1-carbamoylmethyl-2-naphthol.hydrochloride, 598 mg of DCC and 29.5 mg of DMAP, followed by stirring for 2 hours under cooling with ice and then 24 hours under cooling with water. Thereafter, the same procedure as in Example 1 was carried out to obtain 439.5 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05885990 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-d6d7a4c1eecd4a65921669bff4d5ecec |
| Source note | uspto-grants-1999_03 |