HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1419257Generated: November 3, 2026
Acetonitrile → 6-Cyano-1-dimethylcarbamoylmethoxycarbonyl-2-naphthol
https://huagongshe.com/reaction/1419257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 2-Bromo-N,N-dimethylacetamide | HCID 225544 | — |
| Reactant | 6-Cyano-1-carboxy-2-naphthol | HCID 53846357 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 6-Cyano-1-dimethylcarbamoylmethoxycarbonyl-2-naphthol | HCID 54082352 | 78.5% |
Reaction Steps
To 28.4 g of 6-cyano-1-carboxy-2-naphthol were added 350 ml of acetonitrile, 18 ml of triethylamine and 33.2 g of dimethylcarbamoylmethyl bromide, followed by stirring for 24 hours at 70° C. and further 24 hours at room temperature. The resulting precipitate was collected by filtration and washed with water to obtain 31.2 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05885990 |
|---|
| Source dataset | uspto-grants-1999_03 |
|---|
| ORD ID | ord-66aea4075ac74c379b3cd3eae13d178f |
|---|
| Source note | uspto-grants-1999_03 |
|---|
