HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine hydrofluoride → 1-(2-Hydroxy-4-nitrophenyl)-3-phenylthiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine hydrofluoride | HCID 10290782 | — |
| Reactant | N-(2-tert-butyldimethysilyloxy-4-nitrophenyl)-N'-phenyl-thiourea | HCID 15524278 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2-Hydroxy-4-nitrophenyl)-3-phenylthiourea | HCID 3865723 | 77% |
Reaction Steps
N-(2-Hydroxy-4-nitrophenyl)-N'-phenyl-2-thiourea was prepared by treating a solution of N-(2-tert-butyldimethysilyloxy-4-nitrophenyl)-N'-phenyl-thiourea (100 mg, 0.248 mmol) in CH3CN (1 mL) with Et3N·HF (100 uL, 0.62 mmol) in acetonitrile for 10 minutes at 23° C. The solution was concentrated and flushed through a silica plug with EtOAc to afford the desired compound as an orange solid (55 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05886044 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-029278e106594993b2edfe8611c51660 |
| Source note | uspto-grants-1999_03 |