HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → HCID 178516780, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole | HCID 53794522 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178516780 | HCID 178516780 | 36% |
Reaction Steps
The compound (24) (20 mg) obtained in item (13) above was dissolved in methanol (0.4 ml), to which was added a 0.2M sodium methylate solution (0.4 ml) in methanol and the resulting mixture was allowed to stand at room temperature overnight. The reaction solution obtained was neutralized with addition of dry ice, then concentrated to leave a residue and the residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1), affording the titled compound (25) (6.2 mg) as a colorless solid. Yield: 36%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05886167 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-9d6120a78bae44259dfc44240380669a |
| Source note | uspto-grants-1999_03 |