HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → HCID 178516779, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | 4-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-(dimethylaminomethyleneamino)imidazole | HCID 53794521 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium Methoxide | HCID 10942334 | — |
| Product | HCID 178516779 | HCID 178516779 | 30.3% |
Reaction Steps
Compound (41) (18 mg) obtained in item (8) above was dissolved in a 0.1M sodium methylate solution (0.72 ml) in methanol, and the resultant solution was allowed to stand at room temperature overnight. The reaction solution as formed was neutralized with addition of dry ice and then concentrated to leave a residue. The residue was purified by silica gel column chromatography (developer: the lower layer of water-methanol-chloroform, 1:2:4), affording the titled compound (42) (4.7 mg) as a colorless solid. Yield: 30%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05886167 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-dfc6ff5146c4499593f0d5eb92ef8570 |
| Source note | uspto-grants-1999_03 |