HCID 54485346, compound → HCID 18661322, compound

HRID 1419490Notes

Reaction equation

HRID 1419490 reaction equation
[F:1][C@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][CH:3]1[N:10]=[N+]=[N-].[H][H]>O1CCOCC1.[Pd]>[F:1][C@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][CH:3]1[NH2:10]

Participants

5

Reactant 2

HCID 54485346HCID 54485346, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18661322HCID 18661322, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

Compound (45) (65.0 mg) was dissolved in dioxane (2 ml) and the solution was catalytically reduced by blowing hydrogen therein in the presence of palladium black as catalyst at room temperature for 1 hour. The resulting reaction solution was filtered and the filtrate was concentrated to afford the titled compound (46) (51.0 mg) as a colorless solid. Yield: 92%.

Workup

  1. customThe resulting reaction solution
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-aff5d250eecd424a8ba830a34ff3e603
Source dataset
uspto-grants-1999_03
Patent number
US05886167

Reaction notes

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