HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Methyl 2-fluorophenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Benzeneacetic acid, 2-fluoro- | HCID 67979 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-fluorophenylacetate | HCID 2733230 | 22,016.1% |
Reaction Steps
p-Toluenesulfonic acid (20 mg) was added to a solution of 2-fluorophenyl acetic acid (3.8 g, 24.65 mmol) in methanol (29 ml). After heating the reaction mixture for 1 h on the steam bath, the solvent was removed in vacuo. Filtration through a pad of silica gel (ethyl acetate/hexanes 10/90) gave methyl 2-fluorophenylacetate (4.3 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05886178 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-819dedee4f5647b3b1db7df374e70f86 |
| Source note | uspto-grants-1999_03 |