Methyl pyrazinoate → HCID 15508341, compound

100 ml of methyl acetate, 7.8 g of methyl pyrazinecarboxylate (prepared according to Example 1) and 1.5 g of palladium on activated charcoal (10% Pd) were placed in a 500 ml autoclave. The autoclave was flushed twice with nitrogen and twice with hydrogen, the gas being introduced under a pressure of up to 8 bar and allowed to expand again. Hydrogenation was then carried out for 9 hours at 20° C. and a hydrogen pressure of 10 bar, with stirring. The autoclave was then flushed with nitrogen, the reaction mixture was filtered on a suction filter (0.45 μm pore width) and the catalyst was washed with methyl acetate. Crude methyl 1,4,5,6-tetrahydropyrazine-2-carboxylate was obtained by concentration. Other data concerning the title compound was:

1. customThe autoclave was flushed twice with nitrogen and twice with hydrogen
2. additionthe gas being introduced under a pressure of up to 8 bar
3. customThe autoclave was then flushed with nitrogen
4. filtrationthe reaction mixture was filtered on a suction
5. filtrationfilter (0.45 μm pore width)
6. washthe catalyst was washed with methyl acetate

ORD record

ord-6735abeb34d44f46b0bd058d101953d0

Source dataset

uspto-grants-1999_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05886181