HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (E)-3-(2-nitrothien-5-yl)-2-[(pyridin-2-yl)sulfonyl]acrylonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Nitrothiophene-2-carboxaldehyde | HCID 78281 | — |
| Reactant | 2-Pyridinesulfonylacetonitrile | HCID 519355 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (E)-3-(2-nitrothien-5-yl)-2-[(pyridin-2-yl)sulfonyl]acrylonitrile | HCID 15410661 | 46.7% |
Reaction Steps
2-Nitrothiophen-5-carboxaldehyde (0.157 g) and 2-pyridinesulphonylacetonitrile (0.2 g) were stirred in 2 mL of ethanol containing 0.01 mL piperidine for four hours at 100° C. The mixture was cooled to room temperature and water was added for crystalization. The crude product was filtered and recrystalized from ethanol and water to give 0.15 g of (E)-3-(2-nitrothien-5-yl)-2-[(pyridin-2-yl)sulfonyl] acrylonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05886195 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-aaae46cd41f248e7ad73cc29d43850f3 |
| Source note | uspto-grants-1999_03 |