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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1419558Generated: November 1, 2026

Thionyl Chloride → (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride

https://huagongshe.com/reaction/1419558

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant(S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acidHCID 13118566—
Product(S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chlorideHCID 5386260096.3%

Reaction Steps

Add 32.8 g (0.275 mole) of thionyl chloride to 42 g (0.17 mole) of the obtained (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid, heat with stirring under reflux for 4 hours, and then distill off the unreacted thionyl chloride to give 43 g of (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05886207
Source datasetuspto-grants-1999_03
ORD IDord-db87fbd03d0f4a90be8b6a87dea97c58
Source noteuspto-grants-1999_03