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HRID1419559

反应详情

EQUATION

反应方程式

HRID 1419559 的结构方程式

REACTANTS

反应物

2
结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：CC(C)[C@H](C(=O)O)c1ccc(OC(F)F)cc1
HCID13118566

Benzeneacetic acid, 4-(difluoromethoxy)-α-(1-methylethyl)-

C12H14F2O3

PRODUCTS

生成物

1
结构：CC(C)[C@H](C(=O)Cl)c1ccc(OC(F)F)cc1
HCID53862600

未命名化合物

收率 91.8%

PROCEDURE

实验过程

Add 32.8 g (0.275 mole) of thionyl chloride to 42 g (0.17 mole) of the obtained (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid, heat with stirring under reflux for 1 hour, and then distill off the unreacted thionyl chloride to give 41 g of (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride.

WORKUP

后处理

  1. temperatureheat
  2. temperatureunder reflux for 1 hour
  3. distillationdistill off the unreacted thionyl chloride