Hydrochloric Acid → N-[(4-Phenylpiperidin-4-yl)methyl]methanesulfonamide Hydrochloride

Participants

Reaction Steps

Methanolic hydrogen chloride (4M, 40 mL) was added to a stirred, cooled (0° C.) suspension of N-[(1-t-butoxycarbonyl-4-phenylpiperidin-4-yl)methyl]methanesulfonamide (5.65 g, 15.4 mmol) in methanol (20 mL) and the mixture was stirred at room temperature for 20 h. The solvent was evaporated under reduced pressure to give the title compound as a tan solid (4.66 g, 100%), δH (250 MHz, d6 -DMSO) 9.05 (1H, br s), 8.86 (1H, br s), 7.41-7.26 (5H, m), 6.95 (1H, t, J 6.9 Hz), 3.18 (2H, m), 3.05 (2H, d, J 6.9 Hz), 2.70 (2H, m), 2.64 (3H, s), 2.26 (2H, m), and 2.02 (2H, m).

Provenance & Evidence