反应详情

90 mg (0.23 mmol) of 10 in 8 ml of pyridine is introduced, and 50 μl of thionyl chloride is added under argon. It is stirred for 10 minutes at room temperature, poured onto ice water and extracted with ethyl acetate. The organic phase is washed with sodium bicarbonate solution and sodium chloride solution, dried on sodium sulfate, the solvent is removed and the crude product is purified by chromatography on silica gel (mobile solvent: EE:H=1:19; Rf =0.9), whereby 71 mg (0.20 mmol) of title compound 11 is obtained as a colorless oil.

1. additionpoured onto ice water
2. extractionextracted with ethyl acetate
3. washThe organic phase is washed with sodium bicarbonate solution and sodium chloride solution
4. customdried on sodium sulfate
5. customthe solvent is removed
6. customthe crude product is purified by chromatography on silica gel (mobile solvent: EE:H=1:19; Rf =0.9)