Ammonium Chloride → HCID 67591974, compound

Participants

Reaction Steps

469 mg (1 mmol) of 16 is dissolved in 10 ml of THF and mixed at 0° C. with 3.4 ml of methylmagnesium bromide solution (3M in THF). After 3 hours at this temperature, it is hydrolyzed with ammonium chloride solution, extracted with ethyl acetate and dried on sodium sulfate. The solvent is removed, and the residue is purified on silica gel (mobile solvent: EE:H=8.2), whereby 231 mg (0.6 mmol) of title compound 17 is obtained.

Provenance & Evidence